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Technical data of the equinoxpharma.com

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equinox pharma empowering drug discovery home about us executive summary technology positioning inddex™ advantages targets publications services services people overview -- board management -- staff news latest news -- contact contact us you are here: home >> about us about us who we are and what we do executive summary executive summary for equinox pharma welcome to equinox pharma equinox pharma is a computationally-driven logic-based drug discovery company which, in partnership with pharma companies, agrochemical companies, biotechs and medicinal chemistry-based contract research organizations, uses its capability in proprietary logic-based machine learning and chemoinformatics ( inddex™ ), based on the patented sv-ilp method ( patent number 8126823 ), to undertake drug discovery programmes for our clients. equinox pharma is a computationally-driven drug discovery company, which, in partnership with pharma companies, biotechs and medicinal chemistry-based contract research organizations, will use its capability in machine learning and chemoinformatics (together given the descriptor inddex™) to undertake a range of drug discovery collaborations. these collaborations will be based upon ip generated through equinox programmes focused on high value validated drug targets, on the partner’s proprietary data or on data mined specifically to address a target of interest to both parties. -- computationally-driven means that we put computational techniques at the centre of our drug discovery activities rather than use them simply as support to high throughput screening. this allows us to capture the benefits of computational techniques such as speed and efficiency and critically enables us to discover new chemotypes. we are a semi-virtual company using our in silico models to direct the work of external medicinal chemistry and pharmacology providers. equinox pharma uses a proprietary machine-learning technique to learn from a dataset of molecules active against a single target, and generate quanitative logical rules, providing vital chemical insight into the mechanism of activity, which can then be used to search for potentially active molecules in a form of ligand-based virtual screening . -- equinox pharma uses its proprietary logic-based machine-learning technique inddex™ ( i nvestigational n ovel d rug d iscovery by ex ample) to learn from a training dataset of active and inactive molecules from a screening programme to generate quantitative logic-based rules. these rules are in the form of pairwise distances between fragments of substructure, which provide vital chemical insight into the stereochemical and structural requirements for biological activity. we then undertake ligand-based virtual screening using the logic-based rules to search databases of commercially available, or proprietary, libraries of small molecules to identify potentially active molecules. chemical insight: in-silico logic-based drug discovery learns (for example) that a molecule is active if it has fragments of a pyrazole ring and a benzene ring that are 8.2 ± 1.0 angstroms apart. in contrast to other database screening tools, inddex™ is unique in the approach used such that the new structures identified, and predicted to be active, can bear little resemblance to the training data molecules. in this way inddex™ is a leading tool in scaffold-hopping technology. equinox’s customers provide, in confidence, training datasets which are mined to identify new structural “hits”. these hits are further, iteratively optimised using inddex™ technology to generate optimised leads for pre-clinical development. our internal focus is on g-protein coupled receptor (gpcr) targets with application to metabolic and cns diseases, but as our approach is applicable to other groups of drug targets with relevance to many disease areas we anticipate partnered programmes involving a wide range of drug targets. -- equinox pharma was set up to commercialise the world leading research of three senior academics from imperial college london : professors stephen muggleton , mike sternberg , and paul freemont have collaborated over many years developing expertise in the applications of machine learning, chemo- and bio-informatics and protein crystallography to drug discovery. latest news dec 13, 2007 equinox ppu launched equinox launches pay per use service for bioinformatics software. [ more ] jun 05, 2007 website launch equinox pharma ltd launch two new websites. [ more ] subscribe to newsletter email address:  name:  news - equinox pharma news product - latest product news equinox pharma ltd judy cairns incubator bessemer building prince consort road london sw7 2bp tel: +44 (0) 7425138160   fax: +44 (0)20 7594 6824 -- email: copyright © 2007– equinox pharma limited. all rights reserved. equinox pharma limited is registered in england, company number: 4595825

URL analysis for equinoxpharma.com

http://www.equinoxpharma.com/technology-inddex.html
http://www.equinoxpharma.com/execsummary.html
http://www.equinoxpharma.com/contact-contact.html
http://www.equinoxpharma.com/index.html
http://www.equinoxpharma.com/people-overview.html
http://www.equinoxpharma.com/people-board.html#mike_sternberg
http://www.equinoxpharma.com/people-board.html#paul_freemont
http://www.equinoxpharma.com/people-board.html#stephen_muggleton
http://www.equinoxpharma.com/technology-positioning.html
http://www.equinoxpharma.com/technology-publications.html
http://www.equinoxpharma.com/people-board.html
http://www.equinoxpharma.com/services-services.html
http://www.equinoxpharma.com/technology-targets.html
http://www.equinoxpharma.com/technology-advantages.html
http://www.equinoxpharma.com/people-staff.html
imperial.ac.uk

Whois Information

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Domain Name: EQUINOXPHARMA.COM
Registry Domain ID: 92095104_DOMAIN_COM-VRSN
Registrar WHOIS Server: whois.123-reg.co.uk
Registrar URL: http://www.meshdigital.com
Updated Date: 2014-11-10T05:46:08Z
Creation Date: 2002-11-11T15:24:08Z
Registry Expiry Date: 2019-11-11T15:24:08Z
Registrar: 123-Reg Limited
Registrar IANA ID: 1515
Registrar Abuse Contact Email:
Registrar Abuse Contact Phone:
Domain Status: clientDeleteProhibited https://icann.org/epp#clientDeleteProhibited
Domain Status: clientTransferProhibited https://icann.org/epp#clientTransferProhibited
Domain Status: clientUpdateProhibited https://icann.org/epp#clientUpdateProhibited
Name Server: NS.W-DNS.NET
Name Server: NS2.W-DNS.NET
DNSSEC: unsigned
URL of the ICANN Whois Inaccuracy Complaint Form: https://www.icann.org/wicf/
>>> Last update of whois database: 2017-08-28T23:55:41Z <<<

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Registrars.

  REGISTRAR 123-Reg Limited

SERVERS

  SERVER com.whois-servers.net

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DOMAIN

  NAME equinoxpharma.com

  CHANGED 2014-11-10

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STATUS
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clientTransferProhibited https://icann.org/epp#clientTransferProhibited
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NSERVER

  NS.W-DNS.NET 46.101.24.26

  NS2.W-DNS.NET 95.131.252.12

  REGISTERED yes

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